Atpenin A5
CAS No. 119509-24-9
Atpenin A5 ( —— )
Catalog No. M28853 CAS No. 119509-24-9
Atpenin A5 is a potent and highly specific?complex II?inhibitor (IC50?~10 nM). Atpenin A5 is also an effective?mKATP?channel?agonist and cardioprotective agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 311 | Get Quote |
|
5MG | 470 | Get Quote |
|
10MG | 683 | Get Quote |
|
25MG | 1053 | Get Quote |
|
50MG | 1422 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAtpenin A5
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NoteResearch use only, not for human use.
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Brief DescriptionAtpenin A5 is a potent and highly specific?complex II?inhibitor (IC50?~10 nM). Atpenin A5 is also an effective?mKATP?channel?agonist and cardioprotective agent.
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DescriptionAtpenin A5 is a potent and highly specific?complex II?inhibitor (IC50?~10 nM). Atpenin A5 is also an effective?mKATP?channel?agonist and cardioprotective agent.(In Vitro):Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes.(In Vivo):Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). SDH inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected (100 μg/kg) mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number119509-24-9
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Formula Weight366.2
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Molecular FormulaC15H21Cl2NO5
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1[nH]c(=O)c(C(=O)[C@@H](C)C[C@H](C)[C@@H](Cl)CCl)c(O)c1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tanaka M, et al. Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):87-94.
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